Controlling sleeping sickness – a review

Controlling Sleeping Sickness—“When Will They Ever Learn?”

The recent announcement that WHO has approved the use of a combination of nifurtimox and eflornithine to treat chronic Gambian sleeping sickness, caused by Trypanosoma brucei gambiense, is a welcome step in the seemingly interminable process of searching for less toxic drugs to treat this devastating disease [1]. Arsenical drugs were first used in 1905; melarsoprol remains the drug most frequen...

Sleeping Sickness Wakes Again

Sleeping sickness of horses was, as reeentiy as the IQSO's, the most devastating livestock disease in the United States. Horses died by the hundreds of thousands in the Midwestern United States, in California, and along the Atlantic seaboard at a period which coincided with the beginning of the sharp decline in the use of horses on the farm. Losses were so severe in some areas that the inevitab...

Sleeping sickness – human African trypanosomiasis

The Sleeping Sickness of Uganda

34 cases by the same method and found the Trypanosoma in 20 cases, or 70 per cent. An examination of 12 cases of other diseases including three of Trypanosoma fever in the same way gave negative results. The matter was then taken up by" Lieutenant-Colonel David Bruce, F.n.c.s., R A M C and Dr. David N. Nabarro, who had been deputed by the Royal Society to investigate sleeping sickness, and arri...

Sleeping Sickness in Principe Island

years' war against sleeping sickness in the Island of Principe, a Portuguese Island oft' the West Coast of Africa. The report has been written by Drs. da Costa, Saut Anna, dos Santos, and de A. Alvares, and has been admirably translated into English by Lieutenant-Colonel J. A. Wyllie, f.k.g.s.. of the Indian Army (retd.). The population of the Island of Principe is between 4,000 and 5,000, and ...